Hopefully this means that Nintendo has plenty of games to show off at E3, but 3 new games were unveiled for 3DS before E3. A new Castlevania title, titled Castlevania: Lords of Shadow - Mirror of Fate, was revealed in Nintendo Power and is supposed to be a 2.5D perspective Castlevania. My guess is this game will be similiar to the awesome Castlevania games from GBA/DS and be 2D with a little depth in some areas.
Natsume unveiled Harvest Moon: A New Beginning for 3DS and stated more details will be available at this year's E3. So if you like farm-simming, tune into E3 this year.
Last but not least, a new Shin Megami Tensei game, number 4 to be exact, has been unveiled by Atlus and that will be on its way to the 3DS in the future.